PTMVision: An Interactive Visualization Platform for Post-Translational Modifications of Proteins

Abstract

In recent years, proteins have been shown to carry many more post-translational modifications (PTMs) than originally thought. The visualization of proteins along with their PTMs facilitates exploration and understanding of the effects of these PTMs on the protein structure, function, and interactions with other proteins. Therefore, we developed PTMVision, an interactive webbased visualization. We combine information about PTMs in the primary sequence with a two-dimensional representation of the protein's tertiary structure using a presence-absence map and a modified contact map that relates PTMs with the spatial arrangement of proteins without the need of a 3D structure. The prototype of PTMVision is part of the TueVis Visualization Server and is available at https://ptmvision-tuevis.cs.uni-tuebingen.de/.